TP53 gene and leiomyosarcoma (LMS) risk
PROJECT 2: Understanding the role of TP53 in LMS development
This project looks at whether inherited changes in the TP53 gene and other DNA-repair genes raise the chance of developing leiomyosarcoma for people and their families.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11193260 on NIH RePORTER |
What this research studies
If you participate, researchers will collect genetic information and family cancer histories from people with LMS and their relatives using large population and sarcoma study databases. They'll examine inherited TP53 variants and other DNA damage response genes to see how often they occur in LMS patients and their families. The team combines Utah population records and the International Sarcoma Kindred Study to build the largest LMS genetic dataset to date. Results may help guide recommendations about genetic testing and family risk counseling.
Who could benefit from this research
Good fit: Adults diagnosed with leiomyosarcoma, particularly those with a personal or family history of cancer or early-onset tumors, are the most relevant candidates.
Not a fit: People without LMS or without a related family cancer history are unlikely to see direct benefit from this project.
Why it matters
Potential benefit: Could help more people with LMS and their families learn about inherited cancer risk and get appropriate genetic testing and counseling.
How similar studies have performed: Smaller prior studies have linked TP53 and other DNA-repair genes to LMS, but this larger, comprehensive analysis is novel.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Thomas, David — University of Michigan at Ann Arbor
- Study coordinator: Thomas, David
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.