Toward long-term HIV control for infants, children, and teens
Pediatric Adolescent Virus Elimination (PAVE) Martin Delaney Collaboratory
Developing new lab and preclinical approaches to remove hidden HIV in babies, children, and adolescents so they might safely stop daily HIV medicines.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11401634 on NIH RePORTER |
What this research studies
This project focuses on how HIV hides in the immune cells of infants and children and how those hiding places change over time. Researchers will test immune-based treatments, including broadly neutralizing antibodies and other strategies, and check safety and activity in lab and preclinical models. The team will improve lab, imaging, and immunologic tests to detect viral reservoirs and to measure whether treatments work. The work is meant to pave the way for future human studies and involves community engagement with families affected by pediatric HIV.
Who could benefit from this research
Good fit: Children and adolescents who acquired HIV perinatally or early in life and who are currently on antiretroviral therapy are the main group this work is intended to help.
Not a fit: Adults who acquired HIV as adults and people without HIV are unlikely to benefit directly from this pediatric-focused effort.
Why it matters
Potential benefit: If successful, this work could lead to therapies that let children and adolescents control HIV without lifelong daily antiretroviral therapy.
How similar studies have performed: Some adult and animal studies using broadly neutralizing antibodies and reservoir-targeting strategies have shown promising results, but pediatric-specific approaches are still early and mainly preclinical.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Persaud, Deborah — Johns Hopkins University
- Study coordinator: Persaud, Deborah
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.