Tools to study HIV antibodies and immune receptors
Physical Resources Core
This project builds validated tools and sample collections to help researchers link different kinds of antibodies and immune receptor genes to protection against HIV in people and rhesus macaques.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11161532 on NIH RePORTER |
What this research studies
If I have or am at risk for HIV, this program helps researchers by creating validated reagents, samples, and genetic datasets about antibody Fc regions and Fc receptors from people and rhesus macaques. The team sequences Fc receptor genes, analyzes how antibody types and receptor variants interact, and connects genetic differences to antibody functions. The core supplies standardized reagents and samples to vaccine and antibody studies and provides data analysis to make animal study results more predictive for people. That could make vaccine and antibody research faster and more reliable.
Who could benefit from this research
Good fit: People living with HIV or people at risk of HIV who are willing to donate blood or other samples for research or to join related vaccine or antibody studies would be most relevant.
Not a fit: People not affected by HIV, those unwilling to provide samples, or anyone seeking an immediate clinical therapy rather than research likely will not benefit directly from participation.
Why it matters
Potential benefit: If successful, this work could improve how well monkey vaccine and antibody tests predict protection in people, speeding development of effective HIV vaccines and antibody treatments.
How similar studies have performed: Past studies have shown antibody Fc interactions matter for protection in animals and some human work, but this core aims to systematically link genetic diversity to function across species to fill important gaps.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Pollara, Justin Joseph — Duke University
- Study coordinator: Pollara, Justin Joseph
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.