Tools to map m6A RNA changes in cancer
m6A-suite: an informatics pipeline and resource for elucidating roles of m6A epitranscriptome in cancer
This project builds computer tools and a searchable resource to map m6A RNA chemical marks in cancer so researchers can find potential diagnostic markers and drug targets.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11211069 on NIH RePORTER |
What this research studies
This project will create a software toolbox and online database that pinpoints where m6A chemical marks occur on RNA in normal tissues and cancers. The team will improve methods to detect single-base m6A sites from sequencing data and predict how m6A changes affect gene activity. They will collect and organize existing cancer m6A profiling data and work with lab collaborators to link m6A patterns to cancer behaviors. Over time this resource will let scientists search for specific m6A changes across cancer types and generate leads for new tests or treatments.
Who could benefit from this research
Good fit: People with cancer who are willing to share tumor samples, genetic data, or clinical information with researchers would be the best candidates to contribute to or benefit from this work.
Not a fit: Healthy people and cancer patients who do not provide samples or data are unlikely to receive direct benefits from this project.
Why it matters
Potential benefit: If successful, this resource could help researchers discover new cancer biomarkers and targets that may lead to better diagnostics or therapies.
How similar studies have performed: Related informatics tools and initial m6A studies have produced promising biological leads, but single-base detection and a comprehensive cancer-focused m6A database remain novel goals.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Huang, Yufei — University of Pittsburgh at Pittsburgh
- Study coordinator: Huang, Yufei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.