Tools to determine genetic ancestry from cancer data
Official title: Computational tools for accurate inference of genetic ancestry from cancer-derived molecular data
Funded at Cold Spring Harbor Laboratory · NIH-11078334 · Data updated 2026-11-12
This study is looking to create tools that help understand how a person's genetic background might affect their cancer, using information from their cancer samples without needing any extra personal details, so it’s open to everyone.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cold Spring Harbor Laboratory NIH-funded |
| Lab location | 1 site (Cold Spring Harbor, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $464,331 |
| NIH project number | 5U01CA289357-02 |
| Project ID | NIH-11078334 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include cancer patients from diverse ancestral backgrounds who are willing to provide tumor samples for analysis.
✕Less likely to help
Patients who do not have cancer or those whose tumors cannot be analyzed for molecular data may not benefit from this research.
What this research studies
This research aims to develop computational tools that can accurately infer a patient's genetic ancestry using molecular data derived from cancer samples. By analyzing large datasets from cancer profiles and archival tumor tissues, the project seeks to uncover the relationship between genetic ancestry and cancer characteristics, such as incidence and severity. Patients will not need to provide their cancer-free genetic information or self-identify their race or ethnicity, making the process more inclusive and comprehensive. The goal is to enhance our understanding of how ancestry influences cancer biology and outcomes.
Why it matters
Potential benefit: If successful, this research could lead to more personalized cancer treatments based on a patient's genetic ancestry.
How similar studies have gone: Previous research has shown promising results in using genetic data to understand cancer disparities, indicating that this approach has potential for success.
Where this research is happening
-
Cold Spring Harbor Laboratory
Cold Spring Harbor, United States Active
Researchers
- Principal investigator: Krasnitz, Alexander — Cold Spring Harbor Laboratory
- Study coordinator: Krasnitz, Alexander
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.