Tools to analyze gene expression in different blood cell types using advanced computational methods
Computational tools for estimating cell-type-specific effects in bulk RNA-seq and spatial transcriptomics data, using reference single-cell RNA-seq datasets
['FUNDING_OTHER'] · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · NIH-10840284
This study is working on new computer tools to help understand how genes behave in different types of blood cells, using data from various patients to see how these behaviors change with different health conditions and treatments.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (nih funded) |
| Locations | 1 site (MEMPHIS, UNITED STATES) |
| Trial ID | NIH-10840284 on ClinicalTrials.gov |
What this research studies
This research focuses on developing computational tools that can analyze gene expression data from bulk RNA sequencing and spatial transcriptomics, specifically targeting different cell types within blood samples. By leveraging existing single-cell RNA sequencing datasets, the project aims to bridge the gap between tissue-level gene expression and the specific effects observed in individual cell types. This approach will utilize large clinical datasets that include diverse patient information, allowing for a more nuanced understanding of how gene expression varies across different conditions and treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with blood-related disorders or those undergoing treatments that affect blood cell function.
Not a fit: Patients with conditions unrelated to blood cell function or those not participating in clinical data initiatives may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatments by providing insights into how different blood cell types respond to various diseases and therapies.
How similar studies have performed: Other research has shown success in using single-cell RNA sequencing to uncover important biological insights, indicating that this approach has the potential for significant advancements.
Where this research is happening
MEMPHIS, UNITED STATES
- ST. JUDE CHILDREN'S RESEARCH HOSPITAL — MEMPHIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GEELEHER, PAUL — ST. JUDE CHILDREN'S RESEARCH HOSPITAL
- Study coordinator: GEELEHER, PAUL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.