Tools to analyze brain cell types across different species
Official title: RNA Programmable and Scalable Brain Cell Type Tools Across Vertebrates
Funded at Duke University · NIH-11116509 · Data updated 2026-11-12
This study is exploring a new way to look at how brain cells work and communicate with each other, using a special tool that helps scientists track and change the activity of specific brain cells, which could help us better understand brain function and related disorders in different animals.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | May 1, 2025 |
| Project end | February 28, 2030 |
| Funding year | 2025 |
| Award (this year) | $3,138,556 |
| NIH project number | 1U01MH139723-01 |
| Project ID | NIH-11116509 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with neurological conditions or those interested in the genetic and cellular mechanisms of brain function.
✕Less likely to help
Patients with conditions unrelated to brain function or those who do not have access to the research facilities may not receive any benefit from this research.
What this research studies
This research focuses on developing innovative tools to study the structure and function of neural circuits in various brain regions and species at the level of individual cell types. It utilizes a novel RNA-based technology called CellREADR, which allows for the detection and manipulation of specific cellular RNA, enabling researchers to monitor brain cell activity. The approach is designed to be scalable and applicable across different vertebrate species, potentially enhancing our understanding of brain function and disorders. By using viral vectors for delivery, the technology aims to provide precise access to brain tissues.
Why it matters
Potential benefit: If successful, this research could lead to significant advancements in understanding brain function and the development of targeted therapies for neurological disorders.
How similar studies have gone: Other research has shown success with RNA-based technologies in neuroscience, indicating that this approach has the potential for significant breakthroughs.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Huang, Z Josh — Duke University
- Study coordinator: Huang, Z Josh
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.