Tools to analyze brain cell types across different species
RNA Programmable and Scalable Brain Cell Type Tools Across Vertebrates
['FUNDING_U01'] · DUKE UNIVERSITY · NIH-11116509
This study is exploring a new way to look at how brain cells work and communicate with each other, using a special tool that helps scientists track and change the activity of specific brain cells, which could help us better understand brain function and related disorders in different animals.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-11116509 on ClinicalTrials.gov |
What this research studies
This research focuses on developing innovative tools to study the structure and function of neural circuits in various brain regions and species at the level of individual cell types. It utilizes a novel RNA-based technology called CellREADR, which allows for the detection and manipulation of specific cellular RNA, enabling researchers to monitor brain cell activity. The approach is designed to be scalable and applicable across different vertebrate species, potentially enhancing our understanding of brain function and disorders. By using viral vectors for delivery, the technology aims to provide precise access to brain tissues.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with neurological conditions or those interested in the genetic and cellular mechanisms of brain function.
Not a fit: Patients with conditions unrelated to brain function or those who do not have access to the research facilities may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to significant advancements in understanding brain function and the development of targeted therapies for neurological disorders.
How similar studies have performed: Other research has shown success with RNA-based technologies in neuroscience, indicating that this approach has the potential for significant breakthroughs.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HUANG, Z JOSH — DUKE UNIVERSITY
- Study coordinator: HUANG, Z JOSH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.