TNFRSF13B gene differences and risk of kidney transplant rejection
TNFRSF13B polymorphisms and immunity to transplantation
This research looks at whether changes in a gene called TNFRSF13B affect how kidney transplant recipients make antibodies and whether their new kidney is rejected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11142986 on NIH RePORTER |
What this research studies
Researchers will compare TNFRSF13B gene variants in large groups of people who received kidney transplants using existing study cohorts and medical records. They will study donor-specific B cells from blood samples to measure how quickly and strongly those cells make antibodies and how long the antibodies persist. The team will link specific gene variants to antibody behavior and to real transplant outcomes like antibody-mediated rejection. Results will be checked across multiple independent transplant datasets to make the findings more reliable.
Who could benefit from this research
Good fit: Ideal candidates are people who have had a kidney transplant and are willing to share genetic and clinical data or provide blood samples.
Not a fit: People without kidney transplants or those unwilling to share genetic information or samples are unlikely to directly benefit from participating.
Why it matters
Potential benefit: If successful, this work could help predict who is at higher risk of antibody-mediated rejection and guide more personalized immunosuppression after kidney transplant.
How similar studies have performed: Prior work has linked TNFRSF13B changes to altered antibody behavior and shown associations with rejection, but applying these genetic links across large transplant cohorts is relatively new.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Cascalho, Marilia Isabel — Case Western Reserve University
- Study coordinator: Cascalho, Marilia Isabel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.