TNFR2 and sex differences in nerve protection related to MS
TNFR2 sex differences and EAE
This project looks at whether turning on a protein called TNFR2 helps protect brain and spinal cord cells differently in females and males with MS-related inflammation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | George Washington University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project ID | NIH-11247577 on NIH RePORTER |
What this research studies
From a patient's perspective, researchers are using models of MS to compare how males and females respond when the TNFR2 pathway is activated. They will activate TNFR2 on neurons and myelin-producing cells (oligodendrocytes) using genetic and drug-like tools and then measure movement ability and nerve damage. The team will also study a cell-stress pathway called IRE1 to see if it is needed for the protective effects. These experiments are done in a controlled lab setting at George Washington University and are preclinical work aimed at revealing treatments that could later be tested in people.
Who could benefit from this research
Good fit: People with multiple sclerosis, particularly those experiencing neurodegeneration or progressive symptoms, are the eventual intended beneficiaries of therapies derived from this work.
Not a fit: Individuals without MS or whose disease is driven by unrelated mechanisms are unlikely to benefit directly from these specific findings.
Why it matters
Potential benefit: If successful, this work could identify a new way to protect nerves and promote repair in MS, possibly leading to sex-specific therapies that slow disability.
How similar studies have performed: Prior animal and cell studies have shown TNFR2 can promote repair in the nervous system, but the focus on sex differences and the link to IRE1 signaling is novel.
Where this research is happening
Washington, United States
- George Washington University — Washington, United States (Active)
Researchers
- Principal investigator: Bethea, John Roland — George Washington University
- Study coordinator: Bethea, John Roland
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.