TMEM16 proteins that control ion flow and cell membranes
The TMEM16 Family of Ion Channels and Lipid Scramblases
Researchers are studying TMEM16 proteins that help control nerve signals, body temperature, and blood clotting to help people with febrile seizures, certain bleeding disorders, and some neurodegenerative problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11381758 on NIH RePORTER |
What this research studies
This project focuses on TMEM16 proteins that act as calcium-activated ion channels or lipid scramblases in nerve cells. Scientists use high-resolution cryo-EM images to see protein shapes, make targeted changes to specific amino acids, and measure how those changes affect electrical signals in neurons and temperature regulation. They also examine how TMEM16F moves lipids in cell membranes and how that activity links to blood clotting and bleeding disorders. The work combines lab-grown cells, animal models, and connections to human disease findings.
Who could benefit from this research
Good fit: People with a history of febrile seizures, unexplained bleeding disorders (such as Scott syndrome), or neurodegenerative symptoms might eventually be asked to provide samples or join related studies.
Not a fit: Patients with health problems unrelated to ion channel function, thermoregulation, or blood clotting would be unlikely to benefit directly from this specific research.
Why it matters
Potential benefit: If successful, the work could point to new ways to treat febrile seizures, certain bleeding disorders like Scott syndrome, or neurodegenerative conditions by targeting TMEM16 proteins.
How similar studies have performed: Earlier research established TMEM16A/B as calcium-activated chloride channels and solved some structures, so this work builds on solid prior findings though direct therapies remain unproven.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Jan, Lily — University of California, San Francisco
- Study coordinator: Jan, Lily
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.