Tissue-enhanced grafts to improve bone healing
Official title: Tissue Engineering Strategies to Revitalize Allografts
Funded at University of Oregon · NIH-11376988 · Data updated 2026-11-12
A bone graft improvement project aims to help healing of bone defects by adding a tissue-engineered periosteum to allografts.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oregon NIH-funded |
| Lab location | 1 site (Eugene, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $453,887 |
| NIH project number | 5R01AR064200-10 |
| Project ID | NIH-11376988 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with bone defects requiring allograft reconstruction.
✕Less likely to help
Patients not requiring bone grafts or those with conditions that contraindicate stem cell therapies may not benefit.
What this research studies
This project uses a tissue-engineered periosteum that includes stem cells and periosteal cells within a biodegradable gel to wrap decellularized allografts. The goal is to mimic natural periosteum and improve how the graft remodels and integrates with the patient’s bone. The approach combines mesenchymal stem cells, periosteal cells, and hydrogel materials to create a healing-friendly environment around grafts in mice, with potential steps toward human trials. If successful, this work could lead to faster recovery and stronger graft integration for patients needing bone reconstruction.
Why it matters
Potential benefit: If successful, patients could experience better graft integration and fewer failures, potentially reducing the need for additional surgeries.
How similar studies have gone: Early preclinical work has shown improved healing with periosteum-mimicking approaches in animal models, suggesting potential but needing human confirmation.
Where this research is happening
-
University of Oregon
Eugene, United States Active
Researchers
- Principal investigator: Benoit, Danielle S. — University of Oregon
- Study coordinator: Benoit, Danielle S.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.