Tiny particles from lab-grown human brain tissue to aid stroke recovery
Engineering Extracellular Vesicles of Human Brain Organoids for Stroke Therapy
['FUNDING_R01'] · FLORIDA STATE UNIVERSITY · NIH-11301903
This work tests whether tiny membrane-bound particles made by lab-grown human brain tissue can protect the injured brain and help adult stroke survivors recover.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | FLORIDA STATE UNIVERSITY (nih funded) |
| Locations | 1 site (TALLAHASSEE, UNITED STATES) |
| Trial ID | NIH-11301903 on ClinicalTrials.gov |
What this research studies
Researchers grow mini human brain tissues (organoids) from reprogrammed human cells and collect the extracellular vesicles (tiny membrane-bound packets) they release. They will engineer those vesicles to carry helpful microRNA and supportive molecules and study their effects on neuron survival and repair in lab dishes. Promising vesicles will then be tested in animal models of ischemic stroke to see if they reduce damage and improve function, and the team will compare organoid-derived vesicles to those from other stem cell sources and explore delivery with heparin-hyaluronic approaches to improve targeting.
Who could benefit from this research
Good fit: Adults (21+) who have experienced an ischemic stroke and are interested in experimental therapies to improve recovery would be the likely candidates.
Not a fit: Children, people without stroke, and those with hemorrhagic (non-ischemic) strokes are unlikely to benefit from this specific line of work.
Why it matters
Potential benefit: If successful, this approach could lead to a new treatment that protects brain cells after ischemic stroke and improves recovery of function.
How similar studies have performed: Stem cell-derived extracellular vesicles have shown protective effects in animal stroke models before, but using vesicles from human brain organoids and engineering their microRNA cargo is a newer and less-tested approach.
Where this research is happening
TALLAHASSEE, UNITED STATES
- FLORIDA STATE UNIVERSITY — TALLAHASSEE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LI, YAN — FLORIDA STATE UNIVERSITY
- Study coordinator: LI, YAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.