Tiny cell packages released during herpes (HSV-1) infection
Cargo, biogenesis and functions of extracellular vesicles released during HSV-1 infection
['FUNDING_R01'] · UNIVERSITY OF KANSAS MEDICAL CENTER · NIH-11171534
This work looks at how tiny particles cells send out during herpes (HSV-1) infections can change immune responses and affect brain cells linked to Alzheimer's.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF KANSAS MEDICAL CENTER (nih funded) |
| Locations | 1 site (KANSAS CITY, UNITED STATES) |
| Trial ID | NIH-11171534 on ClinicalTrials.gov |
What this research studies
Researchers will isolate and compare two kinds of extracellular vesicles (tiny packets cells release) produced when cells are infected with HSV-1. They will identify what these vesicles carry, including host immune sensors and viral proteins, and test how each vesicle type affects other cells. Experiments use infected cell cultures and laboratory analyses to see which vesicles help the virus and which trigger immune defenses. The team will connect these findings to processes that could worsen Alzheimer's-related brain changes.
Who could benefit from this research
Good fit: People with a history of HSV-1 infection or patients with Alzheimer's disease might be the most relevant candidates for future sample donation or clinical follow-ups related to this work.
Not a fit: Patients without prior HSV-1 exposure or those seeking immediate treatment changes are unlikely to gain direct benefits from this basic laboratory research in the short term.
Why it matters
Potential benefit: If successful, this work could reveal how herpes-related cell signals worsen brain inflammation and point to new ways to prevent or treat Alzheimer-related damage tied to HSV-1.
How similar studies have performed: Previous research has shown extracellular vesicles can carry immune sensors like STING and alter infections, but applying these findings to HSV-1's role in Alzheimer's is a relatively new direction.
Where this research is happening
KANSAS CITY, UNITED STATES
- UNIVERSITY OF KANSAS MEDICAL CENTER — KANSAS CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KALAMVOKI, MARIA — UNIVERSITY OF KANSAS MEDICAL CENTER
- Study coordinator: KALAMVOKI, MARIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease