Timing of 5-Aminosalicylic Acid Treatment for Ulcerative Colitis
Chronotherapy of 5-Aminosalicylic Acid in Ulcerative Colitis: A Randomized Crossover Trial
This study is looking at whether taking a common ulcerative colitis medication called 5-ASA at certain times of the day can help improve your health and reduce side effects, and it's for people with inactive UC who still have some inflammation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project ID | NIH-10598060 on NIH RePORTER |
What this research studies
This research investigates how the timing of taking 5-aminosalicylic acid (5-ASA), a common medication for Ulcerative Colitis (UC), can affect treatment outcomes. By aligning the medication schedule with the body's natural circadian rhythms, the study aims to enhance the drug's effectiveness and reduce side effects. The trial will involve 60 participants with inactive UC who still show signs of inflammation, testing whether taking the medication at specific times can improve their condition. Participants will be monitored over six months to assess changes in inflammation and overall health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with inactive Ulcerative Colitis who still exhibit subclinical inflammation.
Not a fit: Patients with active Ulcerative Colitis or those who are not currently taking 5-ASA may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients with Ulcerative Colitis, potentially reducing the need for more aggressive therapies.
How similar studies have performed: While the concept of chronotherapy is gaining interest, this specific approach to optimizing 5-ASA treatment timing in UC is relatively novel and has not been extensively tested.
Where this research is happening
Charleston, United States
- Medical University of South Carolina — Charleston, United States (Active)
Researchers
- Principal investigator: Swanson, Garth R — Medical University of South Carolina
- Study coordinator: Swanson, Garth R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.