Timing heart hormones and blood pressure medicines to improve nighttime blood pressure
Natriuretic Peptide-Renin-Angiotensin-Aldosterone System Rhythm Axis and Nocturnal Blood Pressure
See if taking a medicine at night that raises heart hormone levels helps obese adults with high blood pressure get healthier nighttime blood pressure drops.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-11249139 on NIH RePORTER |
What this research studies
You would join a project for obese adults who have high blood pressure that does not drop at night. Researchers plan to give a drug that raises natriuretic peptide levels and also reduces RAAS activity at night to try to realign the 24-hour hormone and blood pressure rhythm. Participants will wear ambulatory blood pressure monitors around the clock and have blood samples taken to track hormone timing. The team will compare nighttime dosing with usual care to see if nighttime blood pressure dipping improves.
Who could benefit from this research
Good fit: Adults with obesity and hypertension who show a non-dipping nighttime blood pressure pattern and can attend clinic visits and wear an ambulatory blood pressure monitor are the best fit.
Not a fit: People who are not obese, who already have normal nighttime blood pressure dipping, or who cannot take neprilysin-inhibiting drugs due to medical contraindications likely would not benefit.
Why it matters
Potential benefit: If successful, this could restore healthier nighttime blood pressure drops and lower the risk of heart attack, stroke, and other cardiovascular problems in obese adults with high blood pressure.
How similar studies have performed: Drugs that boost natriuretic peptides have helped patients with heart failure and can lower blood pressure, but using nighttime dosing specifically to re-synchronize hormone rhythms and fix non-dipping nocturnal blood pressure is a relatively new approach with limited direct evidence.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Arora, Pankaj — University of Alabama at Birmingham
- Study coordinator: Arora, Pankaj
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.