Ticks transmit viruses to humans through tiny particles called exosomes.
Arthropod exosomes mediate vector-pathogen interactions
['FUNDING_R01'] · UNIVERSITY OF TENNESSEE KNOXVILLE · NIH-10668352
This study is looking at how ticks can pass on viruses to humans using tiny particles called exosomes, and it's aimed at helping us understand how to prevent tick-borne diseases like tick-borne encephalitis.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TENNESSEE KNOXVILLE (nih funded) |
| Locations | 1 site (KNOXVILLE, UNITED STATES) |
| Trial ID | NIH-10668352 on ClinicalTrials.gov |
What this research studies
This research investigates how ticks, which are known to carry viruses that can infect humans, use small particles called exosomes to transfer viral RNA and proteins to human cells. By studying a specific virus related to tick-borne encephalitis, the researchers aim to understand the mechanisms of virus transmission from ticks to humans. The study involves analyzing exosomes from tick cell lines and their interaction with human skin and blood cells, using advanced techniques like cryo-electron microscopy and gel electrophoresis. The findings could provide insights into preventing tick-borne diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are at risk of tick-borne diseases, particularly those living in endemic areas.
Not a fit: Patients who do not live in areas where ticks are prevalent or who are not at risk for tick-borne diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing tick-borne diseases in humans.
How similar studies have performed: Other research has shown success in understanding vector-pathogen interactions, but this specific approach using tick exosomes is relatively novel.
Where this research is happening
KNOXVILLE, UNITED STATES
- UNIVERSITY OF TENNESSEE KNOXVILLE — KNOXVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SULTANA, HAMEEDA — UNIVERSITY OF TENNESSEE KNOXVILLE
- Study coordinator: SULTANA, HAMEEDA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.