Thinking and daily functioning in teens and young adults treated for childhood medulloblastoma
Outcomes in AYA survivors of pediatric medulloblastoma.
This project looks at how treatment, genes, and life conditions relate to thinking and daily skills in people who had medulloblastoma as children and are now adolescents or young adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11109643 on NIH RePORTER |
What this research studies
You would be asked to share medical history, complete questionnaires about school, home, and caregiving, provide a DNA sample, and take standardized tests of thinking and everyday skills. The study enrolls survivors from several NCI-designated cancer centers and combines clinical treatment data (like age at treatment and chemo/radiation intensity) with genetic markers and measures of neighborhood and family resources. Researchers will compare these factors to understand why some survivors have mild thinking problems while others have more severe difficulties. The team plans to use this information to identify who is most at risk and what kinds of supports might help.
Who could benefit from this research
Good fit: Ideal candidates are adolescents and young adults who were treated for pediatric medulloblastoma (cerebellar tumors), especially those who received chemotherapy and/or cranial radiation.
Not a fit: People without a history of medulloblastoma or whose cognitive concerns come from unrelated conditions are unlikely to benefit directly from this project.
Why it matters
Potential benefit: If successful, the work could help identify survivors most likely to have thinking and daily-life difficulties so they can get targeted follow-up and support.
How similar studies have performed: Previous research has linked treatment exposures to later thinking problems, but combining genetics with social and caregiving factors to predict outcomes is a more recent and less-tested approach.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: King, Tricia Z. — Emory University
- Study coordinator: King, Tricia Z.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.