Thiamine's effect on brain function in older adults after heart surgery
Thiamine Intervention and Cognition in Older Adults Undergoing Coronary Artery Bypass Grafting- A Randomized Clinical Trial
This study is looking at whether taking thiamine, a vitamin that helps with energy, can boost brain function in older adults aged 60 to 80 who are having heart surgery, with the hope of making their recovery easier and improving their quality of life.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10811014 on NIH RePORTER |
What this research studies
This research investigates whether thiamine, a vitamin essential for energy metabolism, can help improve cognitive function in older adults who are undergoing coronary artery bypass grafting (CABG). The study will involve 52 participants aged 60 to 80, who will be randomly assigned to receive either thiamine or a placebo. Researchers will assess cognitive performance and measure thiamine levels in the blood to determine if thiamine can mitigate cognitive decline associated with heart surgery. The goal is to explore a low-cost intervention that could enhance recovery and quality of life for these patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults aged 60 to 80 who are scheduled to undergo coronary artery bypass grafting.
Not a fit: Patients who are younger than 60 or those not undergoing CABG may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved cognitive outcomes and quality of life for older adults recovering from heart surgery.
How similar studies have performed: Previous research has shown that thiamine supplementation can positively impact metabolic processes, but this specific application in post-CABG cognitive recovery is novel.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Kumar, Rajesh — University of California Los Angeles
- Study coordinator: Kumar, Rajesh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.