The Vanderbilt Memory and Aging Program
Vanderbilt Memory & Aging Project
['FUNDING_R01'] · VANDERBILT UNIVERSITY MEDICAL CENTER · NIH-11085290
This program looks at how heart health affects brain changes and memory in older adults, particularly those at risk for Alzheimer's disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VANDERBILT UNIVERSITY MEDICAL CENTER (nih funded) |
| Locations | 1 site (NASHVILLE, UNITED STATES) |
| Trial ID | NIH-11085290 on ClinicalTrials.gov |
What this research studies
This program aims to understand how heart and blood vessel health might contribute to changes in the brain and memory as people get older. Previous work has shown that subtle changes in heart function can be linked to worse memory and changes in brain structure, especially in areas affected by Alzheimer's disease. Researchers believe that the body's natural ways of protecting blood flow to the brain become less effective with age, making the brain more vulnerable. They are particularly interested in how these connections might be stronger in individuals with a genetic risk factor for Alzheimer's disease, even before memory problems become obvious.
Who could benefit from this research
Good fit: Ideal candidates are adults aged 60 and older, including those with and without memory concerns, and those with a genetic risk factor for Alzheimer's disease.
Not a fit: Patients seeking immediate therapeutic interventions for advanced Alzheimer's disease may not directly benefit from this foundational research.
Why it matters
Potential benefit: If successful, this program could help us understand early risk factors for Alzheimer's disease and dementia, potentially leading to new ways to prevent or treat these conditions.
How similar studies have performed: Previous phases of this program have successfully enrolled participants and published findings that support the central ideas being explored.
Where this research is happening
NASHVILLE, UNITED STATES
- VANDERBILT UNIVERSITY MEDICAL CENTER — NASHVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JEFFERSON, ANGELA L. — VANDERBILT UNIVERSITY MEDICAL CENTER
- Study coordinator: JEFFERSON, ANGELA L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia