The role of serotonin in bone health and metabolism
Serotonin and Skeletal Health
This study is looking at how a common type of antidepressant called SSRIs affects bone health and the risk of fractures, so if you're taking these medications, it could help us understand how to keep your bones strong and healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10886783 on NIH RePORTER |
What this research studies
This research investigates how serotonin, a neurotransmitter, affects bone health in humans, particularly focusing on the impact of selective serotonin reuptake inhibitors (SSRIs) on bone metabolism. Using advanced imaging techniques and physical assessments, the study aims to understand the time-dependent effects of SSRIs on bone density and fracture risk. By examining both the direct effects of SSRIs and their influence on muscle function, the research seeks to clarify the mechanisms behind increased fracture risk associated with antidepressant use. This comprehensive approach may provide insights into better management of bone health in patients taking SSRIs.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults aged 21 and older who are currently using SSRIs or have concerns about bone health.
Not a fit: Patients who are not taking SSRIs or do not have any concerns related to bone health may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing fractures in patients using SSRIs, enhancing overall skeletal health.
How similar studies have performed: Previous research has indicated that SSRIs can significantly impact bone health, but this study aims to explore these effects in greater detail, making it a novel approach.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Walker, Marcella Donovan — Columbia University Health Sciences
- Study coordinator: Walker, Marcella Donovan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.