The role of mitochondrial DNA in bleeding after trauma
Mitochondrial DNA in the pathogenesis of post-injury coagulopathy
This study is looking at how a part of your cells called mitochondrial DNA affects blood clotting after injuries, and it aims to help doctors find better ways to treat people who have trouble stopping bleeding after trauma.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Mississippi Med Ctr NIH-funded |
| Lab location | 1 site (Jackson, United States) |
| Project ID | NIH-10890626 on NIH RePORTER |
What this research studies
This research investigates how mitochondrial DNA (mtDNA) contributes to coagulopathy, a condition that affects blood clotting after traumatic injuries. Led by Dr. Matthew Kutcher, a trauma surgeon, the project aims to explore the mechanisms by which mtDNA influences blood coagulation through clinical studies and animal models. Patients may benefit from insights gained about mtDNA's role in bleeding, potentially leading to improved treatment strategies for trauma-induced coagulopathy.
Who could benefit from this research
Good fit: Ideal candidates for this research are trauma patients who are at risk of coagulopathy following their injuries.
Not a fit: Patients who do not have trauma-related injuries or coagulopathy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better management and treatment options for patients experiencing bleeding complications after trauma.
How similar studies have performed: While the specific focus on mtDNA in trauma-induced coagulopathy is relatively novel, similar research has shown promise in understanding the role of genetic factors in coagulation disorders.
Where this research is happening
Jackson, United States
- University of Mississippi Med Ctr — Jackson, United States (Active)
Researchers
- Principal investigator: Kutcher, Matthew E — University of Mississippi Med Ctr
- Study coordinator: Kutcher, Matthew E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.