The role of METTL3 in how exercise benefits the heart in diabetes
Official title: METTL3 in Cardiac Benefits of Exercise in Diabetes
Funded at Massachusetts General Hospital · NIH-10776773 · Data updated 2026-11-12
This study is looking at how exercise can help improve heart health for people with diabetes by focusing on a protein called METTL3, and it aims to find new ways to protect the heart from damage caused by diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 5, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $599,921 |
| NIH project number | 1R01HL171201-01 |
| Project ID | NIH-10776773 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with adult-onset diabetes who are experiencing heart-related complications.
✕Less likely to help
Patients without diabetes or those who do not have any cardiac complications may not benefit from this research.
What this research studies
This research investigates how exercise can improve heart health in patients with diabetes, focusing on a specific protein called METTL3. The study aims to understand the molecular mechanisms behind the heart's response to exercise, particularly in the context of diabetic cardiomyopathy, a serious complication of diabetes. By examining how METTL3 is affected by exercise and its role in protecting heart cells from damage, the researchers hope to uncover new therapeutic strategies for patients with diabetes. The research will involve both laboratory experiments and analysis of heart tissue to explore these relationships.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the heart health of patients with diabetes through exercise.
How similar studies have gone: Previous research has shown promising results in understanding the benefits of exercise on heart health in diabetic models, but the specific role of METTL3 in this context is still being explored.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Li, Haobo — Massachusetts General Hospital
- Study coordinator: Li, Haobo
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.