The role of metabolic processes in gum disease and health.
Metabolic-Purinergic fitness in periodontal health and disease
This study is looking at how a specific enzyme related to energy in our cells might help reduce inflammation and bone loss in gum disease, especially for older adults, and it hopes to find new ways to improve gum health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project ID | NIH-11127197 on NIH RePORTER |
What this research studies
This research investigates how certain enzymes involved in nucleotide metabolism affect inflammation and bone loss in periodontal disease, particularly in older adults. It focuses on the enzyme ecto-5'-nucleotidase (CD73) and its role in converting extracellular ATP to adenosine, which may help control inflammation in gum tissues. By studying the effects of these metabolic processes, the research aims to identify potential biomarkers and therapeutic targets for managing periodontal disease. Patients may be involved in assessments that explore these metabolic pathways and their implications for gum health.
Who could benefit from this research
Good fit: Ideal candidates for participation are individuals aged 65 and older who are experiencing or at risk for periodontal disease.
Not a fit: Patients under the age of 65 or those without periodontal disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments or preventive strategies for periodontal disease, particularly for older adults.
How similar studies have performed: While the specific focus on CD73 in periodontal disease is novel, similar metabolic approaches have shown promise in other inflammatory conditions.
Where this research is happening
Augusta, United States
- Augusta University — Augusta, United States (Active)
Researchers
- Principal investigator: Morandini, Ana Carolina — Augusta University
- Study coordinator: Morandini, Ana Carolina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.