The role of gut bacteria in the risk of developing diabetes.

Human Gut Microbiome and Incident Diabetes Risk in U.S. Populations

NIH-funded research Harvard School of Public Health · NIH-10757359

This study is looking at how the bacteria in your gut might affect your chances of getting type 2 diabetes, and it will also see how your diet plays a role in this relationship.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionHarvard School of Public Health NIH-funded
Lab location1 site (Boston, United States)
Project IDNIH-10757359 on NIH RePORTER

What this research studies

This research investigates how the human gut microbiome may influence the risk of developing type 2 diabetes (T2D) by examining the composition and function of gut bacteria. By analyzing fecal samples, the study aims to identify specific microbial features and metabolic pathways that could be linked to T2D risk. Additionally, it will explore how diet interacts with the microbiome to affect these risks. This comprehensive approach combines advanced methods such as network analysis to provide insights into the relationship between gut health and diabetes.

Who could benefit from this research

Good fit: Ideal candidates for this research are adults aged 21 and older who are at risk of developing type 2 diabetes.

Not a fit: Patients who are not at risk for type 2 diabetes or those with established diabetes may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to new strategies for preventing or managing type 2 diabetes through microbiome-targeted interventions.

How similar studies have performed: Previous studies have shown promising links between gut microbiota and diabetes risk, but this research aims to establish a more definitive prospective relationship.

Where this research is happening

Boston, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.