NIH-funded research NIH-funded research

The role of gut bacteria in cognitive issues related to Parkinson's disease

Official title: Microbiome Composition and Function Contributes to Cognitive Impairment and Neuroinflammation in Parkinson’s Disease

Funded at California State Univ San Bernardino · NIH-10828333 · Data updated 2026-11-12

This study is looking at how the bacteria in your gut might affect thinking and memory problems in people with Parkinson's disease, hoping to find new ways to help improve these symptoms.

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Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionCalifornia State Univ San Bernardino
NIH-funded
Lab location1 site (San Bernardino, United States)
Project startMay 1, 2021
Project endApril 30, 2026
Funding year2024
Award (this year)$106,943
NIH project number5SC3NS124906-04
Project IDNIH-10828333 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are individuals diagnosed with Parkinson's disease who are experiencing cognitive impairment.

Less likely to help

Patients without a diagnosis of Parkinson's disease or those not experiencing cognitive issues may not benefit from this research.

What this research studies

This research investigates how the composition of gut bacteria may influence cognitive impairment and neuroinflammation in individuals with Parkinson's disease. It explores the connection between changes in gut microbiota and cognitive decline, aiming to identify alternative mechanisms that contribute to these symptoms. By analyzing the gut environment and its relationship with cognitive function, the study seeks to uncover new treatment targets and improve prognostic predictions for patients. The research employs a combination of clinical assessments and microbiome analysis to understand these complex interactions.

Why it matters

Potential benefit: If successful, this research could lead to new therapeutic strategies that improve cognitive function in patients with Parkinson's disease.

How similar studies have gone: Previous research has shown promising results linking gut microbiota to cognitive function, suggesting that this approach may yield valuable insights.

Where this research is happening

  • California State Univ San Bernardino
    San Bernardino, United States
    Active

Researchers

  • Principal investigator: Jones, Jacob D — California State Univ San Bernardino
  • Study coordinator: Jones, Jacob D

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.