The role of GDF10 in heart development after birth
Official title: GDF10 in Neonatal Heart Development
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11031323 · Data updated 2026-11-12
This study is looking at how a protein called GDF10 helps heart cells work together during the important early weeks after a baby is born, which could help us learn more about keeping infants' hearts healthy.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | February 1, 2024 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $41,915 |
| NIH project number | 5F31HL168819-02 |
| Project ID | NIH-11031323 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research are newborns and infants with cardiac development issues.
✕Less likely to help
Patients who are older than 21 years or have fully developed hearts may not receive benefit from this research.
What this research studies
This research investigates how GDF10, a protein involved in cell communication, affects the development of the heart in newborns. It focuses on the interactions between cardiomyocytes (heart muscle cells) and fibroblasts (supporting cells) during the critical early weeks after birth. By analyzing gene expression and cellular changes, the study aims to uncover the mechanisms that ensure proper heart function as it matures. Understanding these processes could lead to new insights into heart health and disease in infants.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for heart conditions in newborns and better understanding of heart development.
How similar studies have gone: Other research has shown that understanding cellular communication in heart development can lead to significant advancements in treating heart diseases, suggesting this approach has potential.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Uscategui Calderon, Maria — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Uscategui Calderon, Maria
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.