The role of GDF10 in heart development after birth
GDF10 in Neonatal Heart Development
['FUNDING_FELLOWSHIP'] · CINCINNATI CHILDRENS HOSP MED CTR · NIH-11031323
This study is looking at how a protein called GDF10 helps heart cells work together during the important early weeks after a baby is born, which could help us learn more about keeping infants' hearts healthy.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CINCINNATI CHILDRENS HOSP MED CTR (nih funded) |
| Locations | 1 site (CINCINNATI, UNITED STATES) |
| Trial ID | NIH-11031323 on ClinicalTrials.gov |
What this research studies
This research investigates how GDF10, a protein involved in cell communication, affects the development of the heart in newborns. It focuses on the interactions between cardiomyocytes (heart muscle cells) and fibroblasts (supporting cells) during the critical early weeks after birth. By analyzing gene expression and cellular changes, the study aims to uncover the mechanisms that ensure proper heart function as it matures. Understanding these processes could lead to new insights into heart health and disease in infants.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research are newborns and infants with cardiac development issues.
Not a fit: Patients who are older than 21 years or have fully developed hearts may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for heart conditions in newborns and better understanding of heart development.
How similar studies have performed: Other research has shown that understanding cellular communication in heart development can lead to significant advancements in treating heart diseases, suggesting this approach has potential.
Where this research is happening
CINCINNATI, UNITED STATES
- CINCINNATI CHILDRENS HOSP MED CTR — CINCINNATI, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: USCATEGUI CALDERON, MARIA — CINCINNATI CHILDRENS HOSP MED CTR
- Study coordinator: USCATEGUI CALDERON, MARIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.