The role of fat tissue around blood vessels in lupus-related heart disease
Perivascular adipose tissue in the pathogenesis of lupus vasculopathy
This study looks at how the fat around blood vessels might affect heart health in people with lupus, using a special mouse model to learn more about the inflammation in this fat and how it could lead to heart problems, with hopes of finding new ways to help lupus patients stay heart-healthy.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project ID | NIH-11015813 on NIH RePORTER |
What this research studies
This research investigates how perivascular adipose tissue (PVAT), which is the fat surrounding blood vessels, contributes to cardiovascular disease in patients with systemic lupus erythematosus (SLE). By using a lupus-prone mouse model, the study examines the inflammatory characteristics of PVAT and its impact on vascular function. The researchers aim to understand the biological changes in PVAT that occur in lupus patients and how these changes may lead to increased cardiovascular risks. The findings could provide insights into potential therapeutic targets for improving heart health in lupus patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with systemic lupus erythematosus, particularly those at risk for cardiovascular complications.
Not a fit: Patients without systemic lupus erythematosus or those who do not have cardiovascular disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing cardiovascular disease in lupus patients.
How similar studies have performed: Previous research has indicated that understanding the role of adipose tissue in vascular health can lead to significant advancements in treating cardiovascular diseases, suggesting this approach may yield valuable insights.
Where this research is happening
Augusta, United States
- Augusta University — Augusta, United States (Active)
Researchers
- Principal investigator: Shi, Hong — Augusta University
- Study coordinator: Shi, Hong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.