The role of estrogen in heart health for older women
Official title: Aging and estrogen-dependent HDAC2 regulation: implications in cardiac injury
Funded at Tulane University of Louisiana · NIH-10745739 · Data updated 2026-11-12
This study is looking at how estrogen levels impact heart health in older women, especially how a certain enzyme might play a role in heart disease, to help find new ways to prevent heart problems as women age.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project start | December 1, 2022 |
| Project end | November 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $76,000 |
| NIH project number | 5R03AG075396-02 |
| Project ID | NIH-10745739 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are postmenopausal women who are at risk for cardiovascular disease.
✕Less likely to help
Patients who are not postmenopausal or who do not have cardiovascular risk factors may not benefit from this research.
What this research studies
This research investigates how estrogen levels affect heart health in older women, particularly focusing on the role of a specific enzyme, HDAC2, in cardiovascular disease. It aims to understand how estrogen signaling can protect the heart by regulating this enzyme's expression. The study will explore the differences in these effects between premenopausal and postmenopausal women, with the goal of developing new treatments to prevent heart disease in aging females. By examining these biological mechanisms, the research seeks to provide insights that could lead to effective interventions for cardiovascular issues related to aging.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing heart disease in postmenopausal women.
How similar studies have gone: Previous research has shown promising results in understanding the role of estrogen in heart health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Tulane University of Louisiana
New Orleans, United States Active
Researchers
- Principal investigator: Kumar, Prerna — Tulane University of Louisiana
- Study coordinator: Kumar, Prerna
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.