The role of dietary fiber and specific bacteria in gut health after bone marrow transplantation
Official title: Dietary fiber, mucin-degrading Bacteroides, and intestinal GVHD
Funded at Beckman Research Institute/city of Hope · NIH-10935666 · Data updated 2026-11-12
This study is looking at how eating more fiber and the good bacteria in your gut can help improve health for people getting a bone marrow transplant, especially in managing issues like intestinal graft-versus-host disease, by seeing if changing your diet can make a positive difference in your recovery.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project start | September 21, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $538,160 |
| NIH project number | 1P01HL170046-01A1 |
| Project ID | NIH-10935666 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients who are scheduled to undergo allogeneic bone marrow transplantation and are interested in dietary interventions.
✕Less likely to help
Patients who are not undergoing bone marrow transplantation or those with severe dietary restrictions may not benefit from this research.
What this research studies
This research investigates how dietary fiber and certain bacteria in the gut can influence health outcomes for patients undergoing allogeneic bone marrow transplantation (BMT). By examining the gut microbiome, which consists of trillions of microorganisms, the study aims to understand how dietary interventions can help manage complications like intestinal graft-versus-host disease (GVHD). The approach involves analyzing how dietary fibers can promote beneficial bacteria and suppress harmful ones, potentially improving gut health and overall recovery for patients. Participants may be asked to modify their diets to include specific types of fiber to observe changes in their gut microbiome and health status.
Why it matters
Potential benefit: If successful, this research could lead to dietary recommendations that improve recovery and reduce complications for patients after bone marrow transplantation.
How similar studies have gone: Previous research has shown that dietary interventions can positively influence gut microbiome composition and health outcomes, suggesting that this approach may be effective.
Where this research is happening
-
Beckman Research Institute/city of Hope
Duarte, United States Active
Researchers
- Principal investigator: Martens, Eric C — Beckman Research Institute/city of Hope
- Study coordinator: Martens, Eric C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.