The role of creatine kinase in asthma development and persistence
Official title: Creatine Kinase in the Natural History of Asthma
Funded at University of Arizona · NIH-11115728 · Data updated 2026-11-12
This study is looking at how a substance called creatine kinase might help kids with asthma and whether having more of it could keep asthma from sticking around into adulthood, with the hope of finding new ways to treat and manage asthma.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project start | June 13, 2024 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $193,646 |
| NIH project number | 5R21AI183264-02 |
| Project ID | NIH-11115728 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include children aged 6 years and older who have been diagnosed with asthma.
✕Less likely to help
Patients who do not have asthma or are outside the age range of 6 years and older may not benefit from this research.
What this research studies
This research investigates the relationship between creatine kinase (CK) levels and asthma, particularly in children. It aims to determine if higher levels of CK can protect against the persistence of asthma into adulthood. The study will analyze data from multiple cohorts to validate previous findings and explore whether CK deficits are present in the airways of individuals with asthma. By understanding these mechanisms, the research seeks to uncover potential new avenues for asthma treatment and management.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing asthma from becoming a lifelong condition.
How similar studies have gone: Previous studies have indicated a potential protective role of creatine kinase in asthma, but this research aims to validate those findings in a larger cohort, making it a critical step in understanding this relationship.
Where this research is happening
-
University of Arizona
Tucson, United States Active
Researchers
- Principal investigator: Guerra, Stefano — University of Arizona
- Study coordinator: Guerra, Stefano
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.