The role of chromium in cancer development and blood vessel formation
Chromium in carcinogenesis and angiogenesis
This study is looking at how long-term exposure to a harmful chemical called hexavalent chromium might lead to lung cancer by checking blood samples from people who have been exposed, to see how certain genes related to cancer behave, with the hope of finding new ways to prevent or treat this type of cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Thomas Jefferson University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10447777 on NIH RePORTER |
What this research studies
This research investigates how long-term exposure to hexavalent chromium (Cr(VI)) may lead to lung cancer by examining the biological mechanisms involved. Researchers are analyzing blood samples from individuals exposed to Cr(VI) to identify changes in gene expression, particularly focusing on the IL-8 and CXCL5 genes, which are linked to cancer progression and the formation of new blood vessels. The study employs advanced techniques like genome expression analysis and assays to validate findings, aiming to uncover how these genes contribute to tumor growth and angiogenesis. By understanding these mechanisms, the research seeks to provide insights into potential therapeutic targets for preventing or treating chromium-related cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of exposure to hexavalent chromium, particularly those who are non-smokers.
Not a fit: Patients who have not been exposed to hexavalent chromium or those with other unrelated types of cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating lung cancer associated with chromium exposure.
How similar studies have performed: Other research has shown promising results in understanding the mechanisms of carcinogenesis related to environmental toxins, suggesting that this approach could yield valuable insights.
Where this research is happening
Philadelphia, United States
- Thomas Jefferson University — Philadelphia, United States (Active)
Researchers
- Principal investigator: He, Jun — Thomas Jefferson University
- Study coordinator: He, Jun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.