The role of APOE4 in cognitive impairment caused by cancer chemotherapy
APOE4 promotes pathogenesis in a mouse model of cancer chemotherapy-induced cognitive impairment
This study is looking at how a specific gene, called APOE4, might affect memory and thinking skills in cancer patients who are getting chemotherapy, using mice to learn more about how treatment impacts the brain, with the hope of finding ways to help people keep their mental sharpness during and after treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgetown University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project ID | NIH-10765740 on NIH RePORTER |
What this research studies
This research investigates how the APOE4 gene variant influences cognitive impairment in patients undergoing cancer chemotherapy. By using a mouse model, the study examines the mechanisms through which chemotherapy affects brain functions related to learning, memory, and attention, particularly in those with the APOE4 allele. The researchers aim to identify specific pathways that lead to cognitive decline, which could help in understanding similar effects in humans. The findings may provide insights into how to mitigate these cognitive side effects in cancer patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are cancer patients who carry the APOE4 allele and are experiencing cognitive difficulties related to chemotherapy.
Not a fit: Patients who do not carry the APOE4 allele or who are not undergoing chemotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing or treating cognitive impairment in cancer patients, particularly those with the APOE4 allele.
How similar studies have performed: Previous research has shown that genetic factors like APOE4 significantly influence cognitive outcomes in Alzheimer's disease, suggesting that this approach may yield valuable insights.
Where this research is happening
Washington, United States
- Georgetown University — Washington, United States (Active)
Researchers
- Principal investigator: Rebeck, G William — Georgetown University
- Study coordinator: Rebeck, G William
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.