The role of APOE4 in cognitive impairment caused by cancer chemotherapy

Who could benefit from this research

What this research studies

This research investigates how the APOE4 gene variant influences cognitive impairment in patients undergoing cancer chemotherapy. By using a mouse model, the study examines the mechanisms through which chemotherapy affects brain functions related to learning, memory, and attention, particularly in those with the APOE4 allele. The researchers aim to identify specific pathways that lead to cognitive decline, which could help in understanding similar effects in humans. The findings may provide insights into how to mitigate these cognitive side effects in cancer patients.

Why it matters

Where this research is happening

• Georgetown University
  Washington, United States Active

Researchers

• Principal investigator: Rebeck, G William — Georgetown University
• Study coordinator: Rebeck, G William

Related research

Other NIH-funded projects on the same topics.

• Understanding brain circuit issues in a mouse model of chemotherapy-related cognitive problems

  This study is looking at how a specific gene might change brain function in mice that have memory problems after chemotherapy, with the goal of finding ways to help cancer patients who experience similar issues.

  NIH research Georgetown University · Washington, United States · NIH-11300669

• Understanding brain circuit issues in mice with chemotherapy-related cognitive problems

  This study is looking at how chemotherapy might impact brain function, especially in areas important for memory, in mice that have a genetic risk for Alzheimer's disease, to help us understand why some cancer survivors may experience memory problems after treatment.

  NIH research Georgetown University · Washington, United States · NIH-11088247

• Understanding how chemotherapy affects brain blood vessels and cognition

  This study is looking at how chemotherapy might affect thinking and memory in cancer survivors by examining changes in brain blood vessels, and it's aimed at helping those who have experienced 'chemobrain' to find ways to improve their cognitive health.

  NIH research University of Oklahoma Hlth Sciences Ctr · Oklahoma City, United States · NIH-10997435

• Investigating cognitive decline and aging effects from chemotherapy using baboons

  This study is looking at how chemotherapy might affect thinking and brain aging in cancer patients, using baboons to help us understand these changes better, with the hope of finding ways to help people who experience these side effects.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-10901848

• Predicting cognitive impairment after chemotherapy in breast cancer patients

  This study is looking at how chemotherapy might impact thinking and memory in women with breast cancer, and it aims to help predict who might have trouble with these skills after treatment, so they can get the support they need.

  NIH research University of Texas at Austin · Austin, United States · NIH-10832987

• Improving Neurological Health with Brain Training for Mild Cognitive Impairment (INHANCE-MCI)

  A computer-based brain training program is being tested to help people with mild cognitive impairment maintain thinking skills and daily functioning.

  NIH research Posit Science Corporation · San Francisco, United States · NIH-11626504

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.