The role of adiponectin in brain blood flow and cognitive function in dementia.
Adiponectin on cerebrovascular regulation in vascular cognitive impairment and dementia (VCID)
['FUNDING_R01'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-11004042
This study is looking at how a protein called adiponectin, made by fat cells, influences blood flow and thinking skills in people with memory problems related to blood vessel issues, and it aims to see if a special treatment can help improve brain health and memory.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-11004042 on ClinicalTrials.gov |
What this research studies
This research investigates how adiponectin, a protein produced by fat cells, affects blood flow in the brain and cognitive function in patients with vascular cognitive impairment and dementia (VCID). The study uses a mouse model to explore the relationship between adiponectin levels and cognitive deficits caused by reduced blood flow to the brain. By administering a small-molecule treatment that activates adiponectin receptors, researchers aim to understand how enhancing this pathway can improve cognitive outcomes and brain health.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults experiencing cognitive decline associated with vascular issues.
Not a fit: Patients with cognitive impairment not related to vascular issues or those with other types of dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cognitive function and quality of life for patients with vascular cognitive impairment and dementia.
How similar studies have performed: Previous research has shown promising results in enhancing cognitive function through metabolic regulation, suggesting potential success for this approach.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HU, XIAOMING — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: HU, XIAOMING
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Affective Disorders