The role of ACE2 in gut health and diabetes complications
ACE2 on gut barrier dysfunction and BRB disruption
This study is looking at how a protein called ACE2 impacts gut health and blood sugar levels in people with diabetes, hoping to find new ways to help manage diabetes and its related eye problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-10999405 on NIH RePORTER |
What this research studies
This research investigates how angiotensin converting enzyme 2 (ACE2) affects gut health and blood sugar levels in individuals with diabetes. It focuses on understanding the relationship between ACE2, glucose absorption, and the development of diabetic retinopathy, a common complication of diabetes. By examining how ACE2 influences the gut barrier and glucose regulation, the study aims to uncover new insights into managing diabetes and its complications. Patients may be involved in assessments that explore these mechanisms and their effects on health.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with type 2 diabetes who may experience complications related to blood sugar regulation.
Not a fit: Patients without diabetes or those with type 1 diabetes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing diabetes and preventing complications like diabetic retinopathy.
How similar studies have performed: Previous research has shown promising results regarding the role of ACE2 in diabetes management, suggesting that this approach could yield significant insights.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Grant, Maria Bartolomeo — University of Alabama at Birmingham
- Study coordinator: Grant, Maria Bartolomeo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.