The role of a specific enzyme in heart health and diseases
Lysine Acetyltransferase 6A in Health and Cardiac Diseases
This study is looking at how a protein called KAT6A affects heart health, especially in people with heart diseases, by exploring how ketone bodies—special energy sources for the heart—might help protect against heart failure and lead to new treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-10873835 on NIH RePORTER |
What this research studies
This research investigates how lysine acetyltransferase 6A (KAT6A) affects heart function, particularly in the context of cardiac diseases. It focuses on the relationship between ketone bodies, which are alternative energy sources for the heart, and the acetylation process that may protect against heart failure. By exploring the molecular mechanisms of how ketone bodies influence KAT6A, the research aims to identify potential therapeutic strategies for improving heart health. Patients may benefit from insights that could lead to new treatments for heart conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cardiac diseases or those at risk of developing heart failure.
Not a fit: Patients with non-cardiac conditions or those who do not have any risk factors for heart disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic options for patients with heart diseases by enhancing heart function and preventing heart failure.
How similar studies have performed: Previous research has shown promising results in using ketone bodies for improving heart function, indicating that this approach has potential based on earlier findings.
Where this research is happening
Newark, UNITED STATES
- Rutgers Biomedical and Health Sciences — Newark, United States (Active)
Researchers
- Principal investigator: Nakamura, Michinari — Rutgers Biomedical and Health Sciences
- Study coordinator: Nakamura, Michinari
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.