The relationship between sleep patterns and Alzheimer's disease risk in older adults.
Official title: Lifecourse sleep, cognitive decline and risk of Alzheimer's disease: a pooled cohort study.
Funded at University of California, San Francisco · NIH-11089560 · Data updated 2026-11-12
This study is looking at how problems with sleep over the years might affect thinking skills and the chances of getting Alzheimer's disease, and it's for anyone interested in understanding how sleep can impact brain health as we age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | May 15, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $684,403 |
| NIH project number | 5R01AG083836-02 |
| Project ID | NIH-11089560 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults aged 80 and over who may be experiencing cognitive decline or have concerns about Alzheimer's disease.
✕Less likely to help
Patients who are younger than 80 or do not have any cognitive decline or Alzheimer's disease risk factors may not benefit from this research.
What this research studies
This research investigates how sleep disturbances throughout a person's life may influence cognitive decline and the risk of developing Alzheimer's disease and related dementias. By examining both objective measures, like actigraphy, and subjective reports of sleep quality, the study aims to understand the timing and impact of sleep issues on cognitive health. The research will analyze data from diverse populations to identify patterns and mechanisms linking sleep disturbances to Alzheimer's risk across different life stages.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing Alzheimer's disease by addressing sleep disturbances.
How similar studies have gone: Previous research has shown promising results in understanding the link between sleep disturbances and cognitive decline, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Leng, Yue — University of California, San Francisco
- Study coordinator: Leng, Yue
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.