The relationship between physical activity, function, frailty, and cognitive health in older adults with diabetes.

Physical activity, physical function, and frailty in relation to cognitive impairment and AD/ADRD biomarkers in DPPOS

NIH-funded research Columbia University Health Sciences · NIH-10924060

This study is looking at how staying active and being physically strong can affect brain health in older adults who are pre-diabetic or have type 2 diabetes, and it’s inviting participants to help us learn more about these connections through some fun activities and assessments.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionColumbia University Health Sciences NIH-funded
Lab location1 site (New York, United States)
Project IDNIH-10924060 on NIH RePORTER

What this research studies

This research investigates how physical activity, physical function, and frailty are interconnected with cognitive impairment and related brain changes in older adults who are pre-diabetic or have type 2 diabetes. By analyzing data from the Diabetes Prevention Program Outcomes Study, the project aims to understand how these factors influence cognitive health over time. The study will also explore the role of exercise-related substances and diabetes-related factors in these relationships. Patients may be asked to participate in assessments and interventions related to their physical activity and cognitive health.

Who could benefit from this research

Good fit: Ideal candidates for this research are older adults aged 21 and above who are pre-diabetic or have type 2 diabetes.

Not a fit: Patients who are not diagnosed with pre-diabetes or type 2 diabetes may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved strategies for maintaining cognitive health in older adults with diabetes.

How similar studies have performed: Previous research has shown promising results in understanding the links between physical activity and cognitive health, making this approach both relevant and potentially impactful.

Where this research is happening

New York, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.