The relationship between biological aging and recovery after severe brain injuries
Epigenetic Age and Patient Outcomes after Severe Traumatic Brain Injury
This study is looking at how the aging of your DNA might affect how well you recover after a serious brain injury, and it’s for patients who have gone through that experience, helping to find ways to predict recovery based on both biological and social factors.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11166657 on NIH RePORTER |
What this research studies
This research investigates how biological aging, as measured by epigenetic changes in DNA, affects recovery outcomes for patients who have experienced severe traumatic brain injuries (TBI). By analyzing cerebrospinal fluid samples, the study aims to understand the impact of accelerated biological aging on recovery and the potential role of specific biomarkers in predicting patient outcomes. The research also explores how social factors may influence biological aging in these patients, providing a comprehensive view of recovery dynamics post-injury.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults who have suffered a severe traumatic brain injury and are undergoing recovery.
Not a fit: Patients with mild brain injuries or those who do not have access to cerebrospinal fluid sampling may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved recovery strategies and personalized treatment plans for patients recovering from severe traumatic brain injuries.
How similar studies have performed: Other research has shown promising results in using epigenetic markers to predict health outcomes, suggesting that this approach may yield valuable insights.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Conley, Yvette P — University of Pittsburgh at Pittsburgh
- Study coordinator: Conley, Yvette P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.