The link between obstructive sleep apnea, gut bacteria, and heart disease
Obstructive sleep apnea, the microbiome and cardiovascular disease
This study is looking at how obstructive sleep apnea might change the bacteria in your gut and how that could affect your heart health, and it invites patients to help by sharing samples or information to better understand these connections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11002010 on NIH RePORTER |
What this research studies
This research investigates how obstructive sleep apnea (OSA) affects the gut microbiome and its potential role in cardiovascular disease. By examining the effects of intermittent hypoxia and hypercapnia, which are key features of OSA, the study aims to uncover how these factors may alter gut bacteria and their metabolites, potentially leading to atherosclerosis. The research utilizes advanced sequencing technologies and bioinformatics to analyze changes in gut microbiome ecology and metabolism in response to OSA. Patients may be involved in providing samples or data to help understand these relationships better.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with obstructive sleep apnea, particularly those experiencing cardiovascular issues.
Not a fit: Patients without obstructive sleep apnea or those with unrelated cardiovascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into how treating obstructive sleep apnea might reduce the risk of cardiovascular diseases.
How similar studies have performed: Previous research has shown promising results in understanding the relationship between the gut microbiome and cardiovascular health, suggesting that this approach could yield valuable insights.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Haddad, Gabriel G — University of California, San Diego
- Study coordinator: Haddad, Gabriel G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.