The link between kidney function and preeclampsia in pregnancy
Official title: Impaired Renal Reserve and Preeclampsia
Funded at Cedars-Sinai Medical Center · NIH-10999160 · Data updated 2026-11-12
This study looks at how having kidney problems might increase the chances of developing preeclampsia during pregnancy, especially for women who have had issues like kidney injury or chronic kidney disease, and it uses mouse models to help us understand what happens in the body so we can better support these women.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $250,500 |
| NIH project number | 1R21HD110129-01A1 |
| Project ID | NIH-10999160 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are pregnant women with a history of kidney disease or impaired renal function.
✕Less likely to help
Patients without any history of kidney disease or those not currently pregnant may not benefit from this research.
What this research studies
This research investigates how impaired kidney function affects the risk of developing preeclampsia during pregnancy. It focuses on women with conditions such as prior acute kidney injury or chronic kidney disease, who may struggle to increase kidney filtration rates as needed in pregnancy. By studying mouse models that mimic these conditions, the research aims to uncover the underlying mechanisms and metabolic changes that contribute to preeclampsia. The ultimate goal is to improve understanding and management of preeclampsia in at-risk pregnant women.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment strategies for preeclampsia in women with kidney issues.
How similar studies have gone: Previous studies have shown promising results in understanding the relationship between kidney function and pregnancy complications, indicating that this approach has potential for success.
Where this research is happening
-
Cedars-Sinai Medical Center
Los Angeles, United States Active
Researchers
- Principal investigator: Karumanchi, S. Ananth — Cedars-Sinai Medical Center
- Study coordinator: Karumanchi, S. Ananth
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.