The link between gut bacteria and brain blood flow issues
Gut Microbiota and Cerebral Vascular Disease
['FUNDING_R01'] · CLEVELAND CLINIC LERNER COM-CWRU · NIH-10661628
This study is looking at how the bacteria in your gut might affect your risk of having a stroke by influencing how your blood clots, and it’s especially interested in a substance called TMAO that these bacteria produce; if you’re a patient, you might take part in tests to see how your gut health could relate to your overall brain health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CLEVELAND CLINIC LERNER COM-CWRU (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-10661628 on ClinicalTrials.gov |
What this research studies
This research investigates how gut microbiota may influence the risk of cerebral vascular diseases, particularly ischemic stroke, by affecting platelet function and promoting blood clotting. The study focuses on the metabolite trimethylamine N oxide (TMAO), which is produced by gut bacteria and has been linked to increased platelet reactivity and cardiovascular problems. By examining the relationship between diet, gut bacteria, and stroke risk, the research aims to uncover new insights into how these factors interact and contribute to brain health. Patients may be involved in assessments that explore their gut microbiota and its potential impact on their vascular health.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who may be at risk for cerebrovascular diseases due to factors like diet or existing health conditions.
Not a fit: Patients with non-cerebrovascular conditions or those under 21 years old may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing strokes by targeting gut microbiota and platelet function.
How similar studies have performed: Other research has shown promising results linking gut microbiota to cardiovascular health, suggesting that this approach may yield significant insights.
Where this research is happening
CLEVELAND, UNITED STATES
- CLEVELAND CLINIC LERNER COM-CWRU — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHU, WEIFEI — CLEVELAND CLINIC LERNER COM-CWRU
- Study coordinator: ZHU, WEIFEI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.