The link between blood vessel health and Alzheimer's disease progression
Vasculo-neuronal pathophysiological interface in Alzheimer’s and Atherosclerosis
This study is looking at how heart and blood vessel problems, like narrowed arteries, might make Alzheimer's disease worse, and it's for anyone interested in understanding how blood flow affects brain health in people with Alzheimer's.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11020034 on NIH RePORTER |
What this research studies
This research investigates how cardiovascular diseases, particularly atherosclerosis, contribute to the worsening of Alzheimer's disease. It focuses on understanding the impact of narrowed blood vessels and plaque ruptures on brain function and cognitive decline. By studying the brain vasculature in mice with Alzheimer's pathology, the research aims to uncover specific vulnerabilities and changes in blood flow that may exacerbate cognitive impairment. The findings could lead to new insights into how vascular health influences Alzheimer's disease progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease who also have cardiovascular conditions like atherosclerosis.
Not a fit: Patients without Alzheimer's disease or significant cardiovascular issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing or treating cognitive decline in Alzheimer's patients by targeting vascular health.
How similar studies have performed: Previous research has shown that addressing vascular health can positively impact cognitive function in Alzheimer's patients, suggesting that this approach may be promising.
Where this research is happening
Chicago, United States
- Northwestern University at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Iruela-Arispe, M. Luisa — Northwestern University at Chicago
- Study coordinator: Iruela-Arispe, M. Luisa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.