The impact of uremic toxins on heart disease in kidney patients
Official title: Uremic Toxins and Cardiovascular Disease
Funded at Indiana University Indianapolis · NIH-10878531 · Data updated 2026-11-12
This study is looking at how certain harmful substances that build up in people with chronic kidney disease can affect heart health, and it aims to find out if changing what you eat can help improve heart function and reduce risks for heart problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $718,091 |
| NIH project number | 1R01HL170142-01A1 |
| Project ID | NIH-10878531 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who have chronic kidney disease.
✕Less likely to help
Patients without chronic kidney disease or those with early-stage kidney disease may not benefit from this research.
What this research studies
This research investigates how uremic toxins, which accumulate in patients with chronic kidney disease (CKD), contribute to cardiovascular disease (CVD). It focuses on understanding the mechanisms by which these toxins, such as indoxyl sulfate, affect heart function and structure, particularly leading to conditions like left ventricular hypertrophy and arrhythmias. The study utilizes a rat model that mimics advanced human CKD to explore the effects of dietary interventions on toxin levels and heart health. By identifying non-traditional risk factors for CVD in CKD patients, the research aims to improve risk assessment and treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment strategies for heart disease in patients with chronic kidney disease.
How similar studies have gone: Previous research has shown that addressing uremic toxins can improve cardiovascular outcomes in CKD patients, suggesting a promising avenue for further exploration.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Moe, Sharon M — Indiana University Indianapolis
- Study coordinator: Moe, Sharon M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.