The impact of SERPINE1 deficiency on cardiovascular health in older adults
Official title: Heterozygous SERPINE1 Deficiency Confers Durable Cardiovascular Fitness in Humans
Funded at Northwestern University at Chicago · NIH-11002317 · Data updated 2026-11-12
This study is looking at how a change in a specific gene might help older adults stay heart-healthy as they age, and it’s for anyone interested in understanding how genetics can affect heart health in seniors.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $988,209 |
| NIH project number | 5R35HL171553-02 |
| Project ID | NIH-11002317 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 65 and older, particularly those with cardiovascular concerns or related health issues.
✕Less likely to help
Patients under the age of 65 or those without cardiovascular risk factors may not benefit from this research.
What this research studies
This research investigates how a deficiency in the SERPINE1 gene affects cardiovascular fitness in older adults. By examining a unique community with a natural mutation in this gene, the study aims to understand the relationship between SERPINE1 deficiency and reduced aging-related cardiovascular issues. The approach includes analyzing health data and biological samples from participants to identify potential protective mechanisms against age-related diseases. The findings could lead to new insights into improving cardiovascular health in the aging population.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing cardiovascular health and longevity in older adults.
How similar studies have gone: Previous research has shown promising results regarding the protective effects of SERPINE1 deficiency in animal models, suggesting potential for similar outcomes in humans.
Where this research is happening
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Northwestern University at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Vaughan, Douglas E — Northwestern University at Chicago
- Study coordinator: Vaughan, Douglas E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.