The impact of inactivity and sitting on the risk of Alzheimer’s disease in older adults
Official title: Inactivity, sedentary behavior, and the risk for Alzheimer’s disease in middle aged to older adults
Funded at University of Southern California · NIH-11083578 · Data updated 2026-11-12
This study is looking at how sitting too much might impact brain health and the risk of Alzheimer’s disease in middle-aged and older adults, and it will involve tracking your activity levels to see how staying active can help keep your mind sharp.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project start | April 1, 2022 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $651,124 |
| NIH project number | 5R01AG072445-04 |
| Project ID | NIH-11083578 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are middle-aged to older adults, particularly those who may have high levels of sedentary behavior.
✕Less likely to help
Patients who are already highly active and do not engage in sedentary behaviors may not receive significant benefits from this research.
What this research studies
This research investigates how sedentary behavior, or time spent sitting, affects the risk of developing Alzheimer’s disease and cognitive decline in middle-aged to older adults. By analyzing data from a large cohort, the study aims to understand the relationship between sedentary lifestyles and brain health. Participants may be monitored using activity trackers to assess their physical activity levels and sedentary time, providing insights into how these behaviors influence cognitive function and dementia risk.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for reducing the risk of Alzheimer’s disease through lifestyle modifications.
How similar studies have gone: Previous research has indicated that reducing sedentary behavior can positively impact cognitive health, suggesting that this approach may yield beneficial results.
Where this research is happening
-
University of Southern California
Los Angeles, United States Active
Researchers
- Principal investigator: Raichlen, David — University of Southern California
- Study coordinator: Raichlen, David
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.