The impact of HIV medications on heart health
Official title: Cardiovascular Risk of Antiretroviral Therapy Drugs in HIV
Funded at Oklahoma Medical Research Foundation · NIH-11053535 · Data updated 2026-11-12
This study is looking at how the medications used to treat HIV might affect heart health, especially focusing on a condition that can cause serious heart problems, and it's for people living with HIV who want to understand how their treatment could impact their heart.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma Medical Research Foundation NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $654,015 |
| NIH project number | 5R01HL167656-03 |
| Project ID | NIH-11053535 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who are undergoing antiretroviral therapy.
✕Less likely to help
Patients who are not on antiretroviral therapy or those without HIV may not benefit from this research.
What this research studies
This research investigates how antiretroviral therapy (ART) drugs, which are essential for managing HIV, may contribute to heart problems in people living with HIV. The study focuses on understanding the mechanisms behind cardiac fibrosis, a condition that can lead to sudden death in this population. By examining the role of specific proteins and platelets in the body, the researchers aim to identify whether certain ART regimens increase the risk of heart issues. The ultimate goal is to develop preventive strategies to protect heart health in individuals receiving ART.
Why it matters
Potential benefit: If successful, this research could lead to safer HIV treatment options that minimize cardiovascular risks for patients.
How similar studies have gone: Previous research has indicated potential cardiovascular risks associated with antiretroviral therapy, suggesting that this area of investigation is both relevant and necessary.
Where this research is happening
-
Oklahoma Medical Research Foundation
Oklahoma City, United States Active
Researchers
- Principal investigator: Ahamed, Jasimuddin — Oklahoma Medical Research Foundation
- Study coordinator: Ahamed, Jasimuddin
Related research
Other NIH-funded projects on the same topics.
-
Cardiovascular risk planning and reduction for men with prostate cancer
A program to better predict and reduce heart disease risk in men treated for prostate cancer, especially older patients.
-
Traumatic Stress, Epigenetic Aging, and Heart Risk in Veterans
A large study using Veterans Affairs data to see if traumatic stress and faster biological aging relate to higher risk of stroke and heart disease.
-
Lifestyle plan to protect muscle and heart health for adults with obesity using GLP-1 medications
A real-world trial tests a combined nutrition and resistance-training program versus standard care for adults starting GLP-1 weight loss drugs to preserve lean mass and cardiovascular health.
-
Role of the body's natural cannabis-like system in diabetes progression and heart risk
This grant studies how the body's endocannabinoid system affects the progression from obesity to diabetes and the associated risk for cardiovascular disease in adults.
-
Community and Peer Support for Reducing Cardiovascular Risk
Aims to understand how community and peer programs can help people lower cardiovascular risk, by analyzing existing programs and how their implementation and social support influence outcomes.
-
CardioPredict ML: A smarter way to gauge heart risk before pregnancy
A machine learning tool helps identify women at risk for pregnancy-related heart problems before conception, using health records and prior pregnancy data.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.