The impact of antibiotics on juvenile idiopathic arthritis and treatment response
Antibiotics, Juvenile Idiopathic Arthritis, and Antirheumatic Treatment Response
This study is looking at how taking antibiotics might affect kids with juvenile idiopathic arthritis (JIA) and how well their treatments work, with a special focus on the good bacteria in their gut, to help find better ways to treat JIA in children.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-10442518 on NIH RePORTER |
What this research studies
This research investigates how antibiotic exposure in children may influence the development of juvenile idiopathic arthritis (JIA) and the effectiveness of treatments like methotrexate. It focuses on understanding the role of gut microbiota, which can be disrupted by antibiotics, in immune function and disease response. By examining diverse populations, the study aims to replicate findings from previous European studies and explore how antibiotic use affects treatment variability in JIA. The ultimate goal is to improve treatment strategies for children with JIA by identifying modifiable factors related to antibiotic exposure.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with juvenile idiopathic arthritis, particularly those who have been exposed to antibiotics.
Not a fit: Patients who do not have juvenile idiopathic arthritis or have not been exposed to antibiotics may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment options for children with juvenile idiopathic arthritis.
How similar studies have performed: Previous studies have shown a correlation between antibiotic exposure and immune-related conditions, but this research aims to expand on those findings in a broader population.
Where this research is happening
Newark, UNITED STATES
- Rutgers Biomedical and Health Sciences — Newark, United States (Active)
Researchers
- Principal investigator: Horton, Daniel Benjamin — Rutgers Biomedical and Health Sciences
- Study coordinator: Horton, Daniel Benjamin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.