The impact of antibiotics on juvenile idiopathic arthritis and treatment response
Official title: Antibiotics, Juvenile Idiopathic Arthritis, and Antirheumatic Treatment Response
Funded at Rutgers Biomedical and Health Sciences · NIH-10442518 · Data updated 2026-11-12
This study is looking at how taking antibiotics might affect kids with juvenile idiopathic arthritis (JIA) and how well their treatments work, with a special focus on the good bacteria in their gut, to help find better ways to treat JIA in children.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project start | August 15, 2019 |
| Project end | June 30, 2025 |
| Funding year | 2022 |
| Award (this year) | $466,279 |
| NIH project number | 7R01AR074436-04 |
| Project ID | NIH-10442518 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children diagnosed with juvenile idiopathic arthritis, particularly those who have been exposed to antibiotics.
✕Less likely to help
Patients who do not have juvenile idiopathic arthritis or have not been exposed to antibiotics may not benefit from this research.
What this research studies
This research investigates how antibiotic exposure in children may influence the development of juvenile idiopathic arthritis (JIA) and the effectiveness of treatments like methotrexate. It focuses on understanding the role of gut microbiota, which can be disrupted by antibiotics, in immune function and disease response. By examining diverse populations, the study aims to replicate findings from previous European studies and explore how antibiotic use affects treatment variability in JIA. The ultimate goal is to improve treatment strategies for children with JIA by identifying modifiable factors related to antibiotic exposure.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment options for children with juvenile idiopathic arthritis.
How similar studies have gone: Previous studies have shown a correlation between antibiotic exposure and immune-related conditions, but this research aims to expand on those findings in a broader population.
Where this research is happening
-
Rutgers Biomedical and Health Sciences
Newark, United States Active
Researchers
- Principal investigator: Horton, Daniel Benjamin — Rutgers Biomedical and Health Sciences
- Study coordinator: Horton, Daniel Benjamin
Related research
Other NIH-funded projects on the same topics.
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Deciphering What Drives Juvenile Idiopathic Arthritis in African American Children
This project looks at why African American children with juvenile idiopathic arthritis have more joint damage, using clinical data and genetic information to find factors that may explain the differences.
-
Understanding how T cells make IFN-γ and IL-17 in kids with juvenile arthritis
A doctor-scientist at Vanderbilt is studying why certain immune cells in children with juvenile idiopathic arthritis produce inflammatory signals, with the goal of improving diagnosis and treatment.
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Lung disease linked to systemic juvenile idiopathic arthritis in children
This project looks at how ongoing immune activation and some arthritis medicines may cause lung inflammation and breathing problems in children with systemic juvenile idiopathic arthritis (SJIA).
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Linking JIA Registry with Claims Data to Improve Understanding of Juvenile Arthritis
A study will connect the CARRA JIA patient registry with a large national claims database to see how well registry data match real-world care and outcomes for children with juvenile idiopathic arthritis.
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Investigating the role of viruses and gut bacteria in arthritis flares in children
This study is looking at how certain viruses and bacteria in the gut might affect flare-ups of juvenile idiopathic arthritis in kids, hoping to find clues that could help manage these painful episodes better.
-
Understanding lung disease in children with systemic juvenile idiopathic arthritis
This study is looking at how a serious lung problem in some kids with systemic juvenile idiopathic arthritis happens, and it aims to find new ways to help treat or prevent this issue by understanding how a certain part of their immune system works.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.