The effects of vitamin K on breast cancer
Vitamin K: Body Pools and Function in Breast Cancer
['FUNDING_R01'] · STATE UNIVERSITY OF NEW YORK AT ALBANY · NIH-11016986
This study is looking at how different types of vitamin K might affect aggressive breast cancers, like triple negative breast cancer, to find new ways to help patients by possibly limiting vitamin K in their treatment.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STATE UNIVERSITY OF NEW YORK AT ALBANY (nih funded) |
| Locations | 1 site (ALBANY, UNITED STATES) |
| Trial ID | NIH-11016986 on ClinicalTrials.gov |
What this research studies
This research investigates how different forms of vitamin K influence breast cancer, particularly focusing on aggressive types like triple negative breast cancer (TNBC). It examines the role of gamma-glutamyl carboxylase (GGCX) in breast cancer cells and how vitamin K1 can enhance cancer stem cell characteristics. By analyzing genomic data, the study identifies patients whose tumors express specific genes related to vitamin K metabolism, aiming to develop targeted therapies that could inhibit these pathways. Patients with certain breast cancer subtypes may be eligible for treatments that limit vitamin K availability.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with triple negative breast cancer or other aggressive breast cancer subtypes that express GGCX and VKOR genes.
Not a fit: Patients with non-aggressive breast cancer or those whose tumors do not express the relevant genes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for patients with aggressive breast cancer by targeting vitamin K pathways.
How similar studies have performed: While the specific approach of targeting vitamin K in breast cancer is novel, there is ongoing research into the role of dietary components in cancer treatment, suggesting potential for success.
Where this research is happening
ALBANY, UNITED STATES
- STATE UNIVERSITY OF NEW YORK AT ALBANY — ALBANY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WELSH, JOELLEN — STATE UNIVERSITY OF NEW YORK AT ALBANY
- Study coordinator: WELSH, JOELLEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: advanced breast cancer, advanced stage breast cancer, aggressive breast cancer, Breast Cancer