The effects of traumatic brain injury and repeated head impacts on dementia and related conditions
Traumatic Brain Injury and Repetitive Head Impacts: Contributions to AD/ADRD and CTE Neuropathology and Resulting Clinical Syndromes
This study is looking at how injuries to the brain from things like sports or military activities might lead to dementia and other brain problems, and it’s for anyone interested in understanding the long-term effects of these injuries on brain health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10689889 on NIH RePORTER |
What this research studies
This research investigates how traumatic brain injuries (TBI) and repetitive head impacts (RHI) from activities like contact sports and military service contribute to the development of dementia and other neurological conditions. By examining brain tissue samples, the study aims to identify the various pathological changes associated with TBI and RHI, including the presence of proteins linked to neurodegeneration. The research seeks to understand the long-term effects of these injuries on brain health and the potential for developing conditions such as Alzheimer's disease and chronic traumatic encephalopathy (CTE). Through this work, researchers hope to clarify the relationship between these injuries and the onset of neurodegenerative diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have experienced traumatic brain injuries or repetitive head impacts, particularly athletes or military personnel.
Not a fit: Patients who have not experienced any form of traumatic brain injury or repetitive head impacts may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention strategies for dementia and related conditions in individuals with a history of TBI or RHI.
How similar studies have performed: Previous research has shown promising results in understanding the link between traumatic brain injuries and neurodegenerative diseases, indicating that this area of study is both relevant and necessary.
Where this research is happening
Boston, United States
- Boston University Medical Campus — Boston, United States (Active)
Researchers
- Principal investigator: Mckee, Ann C. — Boston University Medical Campus
- Study coordinator: Mckee, Ann C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.