The effects of seasonal malaria treatment on malaria rates in children in Mali
Official title: The age-specific impact of seasonal malaria chemoprevention on malaria incidence, antibody responses, and parasite reservoirs in Malian children
Funded at Univ of Sciences, Tech & Tech of Bamako · NIH-11060962 · Data updated 2026-11-12
This study is looking at how giving young children in Mali monthly malaria medicine during the malaria season helps protect them from getting sick and how it affects their immune system as they grow up.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Sciences, Tech & Tech of Bamako NIH-funded |
| Lab location | 1 site (Bamako, Mali) |
| Project start | April 23, 2021 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $133,639 |
| NIH project number | 5R01AI150534-05 |
| Project ID | NIH-11060962 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years living in areas with high malaria transmission in Mali.
✕Less likely to help
Patients outside the age range of 0-11 years or those not residing in malaria-endemic regions may not benefit from this research.
What this research studies
This research investigates how seasonal malaria chemoprevention (SMC) affects malaria incidence and immune responses in children in Mali. It involves administering monthly treatments of specific anti-malarial drugs to young children during the malaria season to maintain effective drug levels in their blood. The study aims to understand the long-term impacts of SMC on children's health, particularly regarding their susceptibility to malaria as they grow older. By measuring malaria cases and immune responses, the research seeks to ensure that preventive measures do not inadvertently increase future risks of malaria.
Why it matters
Potential benefit: If successful, this research could lead to improved malaria prevention strategies that protect children while maintaining their immune health.
How similar studies have gone: Previous studies have shown that seasonal malaria chemoprevention can significantly reduce malaria infections in young children, indicating a promising approach.
Where this research is happening
-
Univ of Sciences, Tech & Tech of Bamako
Bamako, Mali Active
Researchers
- Principal investigator: Coulibaly, Drissa — Univ of Sciences, Tech & Tech of Bamako
- Study coordinator: Coulibaly, Drissa
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.